The 500 Cigarettes meme is a moment from a scene in The Orville that’s come to signify seeking out the euphoric—or to poke fun at smokers. The science fiction series features many otherworldly creatures interacting with “human” things, which is essentially the crux of the show’s humor. Where did the 500 Cigarettes meme come from? The 500 cigarettes meme is from the science fiction series The Orville, created by Seth MacFarlane. The show follows the crew of an exploratory space vessel in the 25th century. It heavily parodies the Star Trek universe and other sci-fi movies and games, splicing drama and comedy in the sci-fi-action storylines. What episode of The Orville is the 500 Cigarettes mem... [Read more]